and the ILCHUN GenomicMedicine Institute at Seoul National University

DUBLIN, Ireland(Business Wire)Research and Markets( http://) hasannounced the addition of John Wiley and Sons Ltd's new report "DigitalModelling for Urban Design" to their offering. While there is a rich array of urban theory, design, and representation booksavailable, there is currently no book which brings together, in a single volume,urban design theory and new digital technologies in urban information mapping,modeling, and 3D simulation. Based on two decades of practicing and teachingarchitecture, author Brian McGrath's Digital Modelling for Urban Design exploresthe new theories and technologies of digital modelling, focusing on how tocreate moving and interactive 3D drawing, skills useful in the context of urbantheory, and design and representation. SANTA FE, N.M.(Business Wire)The National Center for Genome Resources (NCGR) announced today that it hasbroken the 20 billion DNA sequence barrier for the first time with an IlluminaGenome Analyzer.

Using a single Illumina flowcell, NCGR scientists generatedmore than 20 billion bases (or letters) of high quality human DNA sequence -seven-times the length of a human genome. This milestone brings significantly closer the ability to decode individualgenomes cost-effectively, which is widely heralded to transform understanding ofhuman disease, its diagnosis and prevention. The individual whose genome was sequenced suffers from multiple sclerosis.Funded by Small Ventures USA, the Brass Family Foundation and the Nancy DavisFoundation, the project was undertaken in collaboration with scientists at theUniversity of California, San Francisco, Department of Neurology and IlluminaInc., and seeks to identify changes in the DNA code that increase risk ofmultiple sclerosis. "This milestone is the result of close collaboration between scientists at NCGRand Illumina," said Ryan Kim, Deputy Director of the NCGR Genome Center. "DNAsequence throughput has been steadily increasing over the last several monthsand we are delighted with the combination of accuracy and throughput that wehave achieved." Technical details: 20.5 billion bases of DNA sequence passed quality metricswith a paired-end library on a Illumina Genome Analyzer II instrument and singleflowcell using improved sequencing chemistry. Human DNA sequence was generatedin seven of eight flowcell channels, creating approximately 13 million sequencesper channel, each of which was 212 bases in length (pairs of 106 basesequences).

The average quality score of the sequence was greater than 25 andaverage error rate was 0.91. In addition, 18.8 billion bases of DNA sequencepassed quality metrics with a long-insert (4000 bases) paired-end library from asingle flowcell on a second individual, also comprising pairs of 106 basesequences. The latter is part of the first Korean genome sequence and was fundedand performed in collaboration with Macrogen Inc. and the ILCHUN GenomicMedicine Institute at Seoul National University.